Search on: SYSTEMS, RESTRICTION MODIFICATION 
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Descriptor English:   DNA Restriction-Modification Enzymes 
Descriptor Spanish:   Enzimas de Restricción-Modificación del ADN 
Descriptor Portuguese:   Enzimas de Restrição-Modificação do DNA 
Synonyms English:   DNA Restriction Modification Enzymes
Restriction Modification Systems
Enzymes, DNA Restriction-Modification
Modification Systems, Restriction
Restriction-Modification Enzymes, DNA
Systems, Restriction Modification
Systems, Restriction-Modification
Restriction-Modification Systems  
Tree Number:   D08.811.150
Definition English:   Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage. 
Indexing Annotation English:   DF: RESTRICT MOD ENZYMES
History Note English:   89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23619 
Unique Identifier:   D015280 

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